Tuesday, January 30, 2007

Who Loves Being Right

This confirms my suspicions. And the real irony is that the legitimate medicine show kills more people then crack, crank, horse and bathtub gin.


Anonymous Adorable Girlfriend said...

The article has so many holes I could drive Air Force One through it.

Let me just take one:

The ABC news report also noted that a survey of clinical trials revealed that when a drug company funds a study, there is a 90% chance that the drug will be perceived as effective whereas a non-drug-company-funded study will show favorable results only 50% of the time. It appears that money can't buy you love but it can buy any "scientific" result desired.

Yeah, ABC news. Because they aren't biased. Even if the story is true and I'm not saying it is, that is true. It's true because teaching hospital and gov't funded studies have different primary objectives and outcomes. Therefore their statistical analyses are going to be different. You are comparing apples to apples to begin with.

Additionally, the FDA decides what drugs get approved. I can put as much spin as I want on it. The FDA runs it's own analyses and they see every study you conduct in support of a drug for approval. There is no buying off the FDA. You pay for your application and you see what the scientists say. In fact most companies work very closely with the FDA scientists during Phase II and III of trials to understand exactly what they need to do to examine a drug in humans.

These reports are so full of bullshit about the drug companies. I've been to the FDA and let me tell you -- it's no day at the beach and these people are not my friends.

ADRs are a problem. However, even more of a problem is the fact that patients are not honest about their current and previous health, they take vitamins and don't tell you and medical records don't follow patients. Thus you have to piece together an accurate picture at the hospital when the patient is in the critical care unit bleeding out. Yeah, because there's the time to go over with him/her how long they've been taking Thorizine and smoking for 25 years and eating McDonald's everyday.

OK, AG is going to stop. Bottom line -- there is so much more to the picture and the real problem lies in quality assurance and what that actually is in healthcare and insurance playing doctor instead of the physician playing doctor and doing what needs to actually be done with a patient and not what someone will pay for or you do because of fear of lawsuits.

Jan 30, 2007, 10:18:00 PM  
Blogger Dean ASC said...

When did the FDA start doing the clinical trials themselves? I thought they relied on the data set that the drug companies supply.

Jan 31, 2007, 6:44:00 PM  
Blogger RicketyFunk said...

Good taters, AG. Your point is valid. I didn't really like the tone of the article either. Their extrapolation of figures yada yada yada and in ten years... 7.4 million people will die because of Bad Doctoring. You can't sell me apples by giving me appleseeds. (that's a good line...)

I'll keep it brief but I have a story I'd like to tell. Funk drank waaay to much one night. Funk threw up A LOT. Funk's stomach hurt real bad for week, especially when eating acetic foods like ketchup or catsup. Funk went to see doctor. Doctor said you puke little ulcers in stomach, don't drink so much FOOL. Give funk scrip for ulcer-go-bye-bye pills. Funk no afford pills. Funk no get pills. Stomach heal on own with diet change and rest. Funk no need pills when funk treat self with respect for once.

Feb 1, 2007, 1:33:00 AM  
Anonymous Adorable Girlfriend said...

The FDA doesn't run trials, Dean. However, every data set you submit to them they review and have the right to question. And believe me -- they question you. They question you all damn day long. Especially if you are a large pharma company like Roche or Pfizer. The biostatisician has to be present at each FDA meeting to review the findings and answer questions they may have. They won't stand for stories of spin and BS. I've seen people get called out during these meetings.

Finally when you go for an NDA after all the data submissions, the FDA actually goes to clinical trial sites that conducted the Phase III trials and reviews patient data for safety and accuracy.

This is when it gets really good because they uncover what kind of shit data you have. I once watched over 50% of human data get thrown out. That meant the company had to re-run the trials.

Believe it or not -- there are systems in place.

Funk, it's true your stomach will heal on it's own. However, many patients have re-occuring ulcers that are very painful. Often an M.D. will prescribe meds for the purpose of not having you come back if you should see it re-occur and be much more painful.

Feb 1, 2007, 8:05:00 PM  
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Hallo! ;)
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Feb 3, 2007, 2:07:00 PM  
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